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KMID : 1037820160050020037
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Journal of Pain and Autonomic Disorders
2016 Volume.5 No. 2 p.37 ~ p.41
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Skin Biopsy and Peripheral Neuropathy
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Suh Bum-Chun
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Abstract
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Skin biopsy is a recently developing tool for neurology. Skin is a very easily accessible human tissue and it is also easy to be used for follow up study. Protein gene product (PGP) 9.5 is a marker for nerve and neuroendocrine cell and is now regarded as pan-axonal marker. In 1990s, skin biopsy protocols using PGP 9.5 antibody for examining intraepidermal nerve fiber density (IENFD) were developed and immunohistochemical fluorescence stain methods with confocal microscopy provided more sophisticated tools for examining dermal adnexa and cutaneous autonomic system. This review might provide introduction to skin biopsy and its application for neurologist.
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KEYWORD
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Biopsy, Nerve fibers, Small fiber neuropathy
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FullTexts / Linksout information
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Listed journal information
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